A Community-Based Study of Factors Associated with Continuing Transmission of Lymphatic Filariasis in Leogane, Haiti
Identifieur interne : 005A80 ( Main/Exploration ); précédent : 005A79; suivant : 005A81A Community-Based Study of Factors Associated with Continuing Transmission of Lymphatic Filariasis in Leogane, Haiti
Auteurs : Alexis Boyd [États-Unis] ; Kimberly Y. Won [États-Unis] ; Shannon K. Mcclintock [États-Unis] ; Catherine V. Donovan [États-Unis] ; Sandra J. Laney [États-Unis] ; Steven A. Williams [États-Unis] ; Nils Pilotte [États-Unis] ; Thomas G. Streit [États-Unis] ; Madsen V. E. Beau De Rochars [Haïti] ; Patrick J. Lammie [États-Unis]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de regroupements, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Enfant, Enfant d'âge préscolaire, Enquêtes et questionnaires, Facteurs de risque, Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Haïti (épidémiologie), Humains, Jeune adulte, Maladies endémiques, Mâle, Observance du traitement médicamenteux (), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Filaricides, Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Haïti.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de regroupements, Enfant, Enfant d'âge préscolaire, Enquêtes et questionnaires, Facteurs de risque, Femelle, Humains, Jeune adulte, Maladies endémiques, Mâle, Observance du traitement médicamenteux, Sujet âgé, Sujet âgé de 80 ans ou plus.
- Wicri :
- geographic : Haïti.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Helminth (blood), Antigens, Helminth (blood), Child, Child, Preschool, Cluster Analysis, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (transmission), Endemic Diseases, Female, Filaricides (therapeutic use), Haiti (epidemiology), Humans, Male, Medication Adherence (statistics & numerical data), Middle Aged, Risk Factors, Surveys and Questionnaires, Young Adult.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- geographic , epidemiology : Haiti.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- statistics & numerical data : Medication Adherence.
- chemical , therapeutic use : Filaricides.
- transmission : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cluster Analysis, Endemic Diseases, Female, Humans, Male, Middle Aged, Risk Factors, Surveys and Questionnaires, Young Adult.
Abstract
Seven rounds of mass drug administration (MDA) have been administered in Leogane, Haiti, an area hyperendemic for lymphatic filariasis (LF). Sentinel site surveys showed that the prevalence of microfilaremia was reduced to <1% from levels as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and 19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk factors related to continued LF transmission and to pinpoint hotspots of transmission. One hundred houses were mapped in each village using GPS-enabled PDAs, and then 30 houses and 10 alternates were chosen for testing. All individuals in selected houses were asked to participate in a short survey about participation in MDA, history of residence in Leogane and general knowledge of LF. Survey teams returned to the houses at night to collect blood for antigen testing, microfilaremia and Bm14 antibody testing and collected mosquitoes from these communities in parallel. Antigen prevalence was highly variable among the 6 villages, with the highest being 38.2% (Dampus) and the lowest being 2.9% (Corail Lemaire); overall antigen prevalence was 18.5%. Initial cluster surveys of 2- to 4-year-old children were not related to community antigen prevalence. Nearest neighbor analysis found evidence of clustering of infection suggesting that LF infection was focal in distribution. Antigen prevalence among individuals who were systematically noncompliant with the MDAs, i.e. they had never participated, was significantly higher than among compliant individuals (p<0.05). A logistic regression model found that of the factors examined for association with infection, only noncompliance was significantly associated with infection. Thus, continuing transmission of LF seems to be linked to rates of systematic noncompliance.
Url:
DOI: 10.1371/journal.pntd.0000640
PubMed: 20351776
PubMed Central: 2843627
Affiliations:
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Donovan</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Laney, Sandra J" sort="Laney, Sandra J" uniqKey="Laney S" first="Sandra J." last="Laney">Sandra J. 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Croix, Leogane</wicri:regionArea><wicri:noRegion>Leogane</wicri:noRegion></affiliation></author><author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (blood)</term><term>Child</term><term>Child, Preschool</term><term>Cluster Analysis</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (transmission)</term><term>Endemic Diseases</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Haiti (epidemiology)</term><term>Humans</term><term>Male</term><term>Medication Adherence (statistics & numerical data)</term><term>Middle Aged</term><term>Risk Factors</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filariose lymphatique (transmission)</term><term>Filariose lymphatique (épidémiologie)</term><term>Haïti (épidémiologie)</term><term>Humains</term><term>Jeune adulte</term><term>Maladies endémiques</term><term>Mâle</term><term>Observance du traitement médicamenteux ()</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Haiti</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Medication Adherence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Filaricides</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Haïti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Cluster Analysis</term><term>Endemic Diseases</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de regroupements</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Enquêtes et questionnaires</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Maladies endémiques</term><term>Mâle</term><term>Observance du traitement médicamenteux</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Haïti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seven rounds of mass drug administration (MDA) have been administered in Leogane, Haiti, an area hyperendemic for lymphatic filariasis (LF). Sentinel site surveys showed that the prevalence of microfilaremia was reduced to <1% from levels as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and 19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk factors related to continued LF transmission and to pinpoint hotspots of transmission. One hundred houses were mapped in each village using GPS-enabled PDAs, and then 30 houses and 10 alternates were chosen for testing. All individuals in selected houses were asked to participate in a short survey about participation in MDA, history of residence in Leogane and general knowledge of LF. Survey teams returned to the houses at night to collect blood for antigen testing, microfilaremia and Bm14 antibody testing and collected mosquitoes from these communities in parallel. Antigen prevalence was highly variable among the 6 villages, with the highest being 38.2% (Dampus) and the lowest being 2.9% (Corail Lemaire); overall antigen prevalence was 18.5%. Initial cluster surveys of 2- to 4-year-old children were not related to community antigen prevalence. Nearest neighbor analysis found evidence of clustering of infection suggesting that LF infection was focal in distribution. Antigen prevalence among individuals who were systematically noncompliant with the MDAs, i.e. they had never participated, was significantly higher than among compliant individuals (p<0.05). A logistic regression model found that of the factors examined for association with infection, only noncompliance was significantly associated with infection. Thus, continuing transmission of LF seems to be linked to rates of systematic noncompliance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Hooper, Pj" uniqKey="Hooper P">PJ Hooper</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Biswas, G" uniqKey="Biswas G">G Biswas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Duke, Bo" uniqKey="Duke B">BO Duke</name></author><author><name sortKey="Karam, M" uniqKey="Karam M">M Karam</name></author><author><name sortKey="Behbehani, K" uniqKey="Behbehani K">K Behbehani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" 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Bockarie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Won, Ky" uniqKey="Won K">KY Won</name></author><author><name sortKey="Beau De Rochars, M" uniqKey="Beau De Rochars M">M Beau de Rochars</name></author><author><name sortKey="Kyelem, D" uniqKey="Kyelem D">D Kyelem</name></author><author><name sortKey="Streit, Tg" uniqKey="Streit T">TG Streit</name></author><author><name sortKey="Lammie, Pj" uniqKey="Lammie P">PJ Lammie</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Haïti</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Indiana</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Boyd, Alexis" sort="Boyd, Alexis" uniqKey="Boyd A" first="Alexis" last="Boyd">Alexis Boyd</name></region><name sortKey="Donovan, Catherine V" sort="Donovan, Catherine V" uniqKey="Donovan C" first="Catherine V." last="Donovan">Catherine V. Donovan</name><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name><name sortKey="Laney, Sandra J" sort="Laney, Sandra J" uniqKey="Laney S" first="Sandra J." last="Laney">Sandra J. Laney</name><name sortKey="Mcclintock, Shannon K" sort="Mcclintock, Shannon K" uniqKey="Mcclintock S" first="Shannon K." last="Mcclintock">Shannon K. Mcclintock</name><name sortKey="Pilotte, Nils" sort="Pilotte, Nils" uniqKey="Pilotte N" first="Nils" last="Pilotte">Nils Pilotte</name><name sortKey="Streit, Thomas G" sort="Streit, Thomas G" uniqKey="Streit T" first="Thomas G." last="Streit">Thomas G. Streit</name><name sortKey="Williams, Steven A" sort="Williams, Steven A" uniqKey="Williams S" first="Steven A." last="Williams">Steven A. Williams</name><name sortKey="Won, Kimberly Y" sort="Won, Kimberly Y" uniqKey="Won K" first="Kimberly Y." last="Won">Kimberly Y. Won</name></country><country name="Haïti"><noRegion><name sortKey="Beau De Rochars, Madsen V E" sort="Beau De Rochars, Madsen V E" uniqKey="Beau De Rochars M" first="Madsen V. E." last="Beau De Rochars">Madsen V. E. Beau De Rochars</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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